The AZURA Cannabis Purifier from Knauer is a scalable, dedicated preparative system for purifying cannabinoids from cannabis extracts. The HPLC layout consists of a pump with ternary LPG valve block and an HPLC docking station equipped with a variable single wavelength UV detector, an injection and a fractionation valve for 11 fractions and waste. The system is designed for method development and small volumes of sample in a flow rate range between 10 to 80 ml/min at maximum 400 bar.
Due to its modular design, the system can easily be scaled up to 200 ml/min by simply replacing the pump head, valves, flow cell and capillaries.
Cannabis contains at least 113 cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinolic acid (THCA), with the CBD accounting for up to 40% of the cannabis plant extract. CBD oil is produced using solvent extraction of cannabis. The chromatogram below illustrates the preparative separation of CBD oil using the Cannabis Purifier.
Chromatograms of the analyses of Fraction 1 and Fraction 2 are shown below, with the BLUE line being before purification and the RED line after purification. Peak 1 is the precursor Cannabigerol, Peak 2 is the Cannabidiol and Peak 3 is Δ9-Tetrahydrocannabinolic acid (Δ9-THCA)
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The Knauer AZURA Cannabis Producer SMB System
For higher levels of purification of cannabinoids take a look at Knauer’s Cannabis Producer SMB System at https://www.knauer.net/en/cannabis-producer-smb-pilot-system-for-continuous-cannabinoid-production/p38308