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Introducing the Cannabis Purifier; the flexible Prep HPLC System for batch purification of single cannabinoids from cannabis extract

Cannabis Purifier HPLC System
Cannabis Purifier HPLC System Flow Path

The AZURA Cannabis Purifier from Knauer is a scalable, dedicated preparative system for purifying cannabinoids from cannabis extracts. The HPLC layout consists of a pump with ternary LPG valve block and an HPLC docking station equipped with a variable single wavelength UV detector, an injection and a fractionation valve for 11 fractions and waste. The system is designed for method development and small volumes of sample in a flow rate range between 10 to 80 ml/min at maximum 400 bar.

Due to its modular design, the system can easily be scaled up to 200 ml/min by simply replacing the pump head, valves, flow cell and capillaries.

Cannabis Purifier Chromatogram

Cannabis contains at least 113 cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinolic acid (THCA), with the CBD accounting for up to 40% of the cannabis plant extract. CBD oil is produced using solvent extraction of cannabis. The chromatogram below illustrates the preparative  separation of CBD oil using the Cannabis Purifier.

Chromatograms of the analyses  of Fraction 1 and Fraction 2 are shown below, with the BLUE line being before purification and the RED line after purification. Peak 1 is the precursor Cannabigerol, Peak 2 is the Cannabidiol and Peak 3 is Δ9-Tetrahydrocannabinolic acid (Δ9-THCA)

Analysis of Fraction 1 of CBD Oil Purification
Analysis of Fraction 2 of CBD Oil Purification
Molecular Structure of Cannabigerol
Molecular Structure of Cannabigerol
Molecular Structure of Cannabidiol
Molecular Structure of Cannabidiol
Molecular Structure of THCA
Molecular Structure of THCA

The Knauer AZURA Cannabis Producer SMB System

Cannabis Producer SMB System

For higher levels of purification of cannabinoids take a look at Knauer’s Cannabis Producer SMB System at https://www.knauer.net/en/cannabis-producer-smb-pilot-system-for-continuous-cannabinoid-production/p38308

Posted in HPLC Systems