Experts in Liquid Chromatography and associated technologies
PROXCYS Downstream Biosystems produces high performance cGMP-compliant lab scale to process chromatography radial columns and offers solutions for fast and safe purification. Proxcys’ Columns offer the highest versatility and DSP throughput per m2 floor space. Proxcys’ Solutions include reliable & robust processes for single step capture from crude feed with packed bed chromatography columns.
Micro RFC Radial Columns
Focusing on the most fundamental characteristic between axial and radial is expressing a radial column as an axial column with a tapered bore. The ratio between the inlet and outlet is equal to the mean ratio found in all Proxcys Radial columns and is 2:1. Therefore a radial mimic Micro-RFC column is a tube-like "axial style" column with a tapered bore.
To ensure close resemblance of hydrodynamics and over-all column behavior, the frits are identical to the larger pilot & process columns. Even the packing process is similar to the larger columns and therewith the packing density will be close.
Laboratory Scale Radial Columns
Full radial columns with short bed height and bed volume between 100ml – 2000ml.
Ideally suited for small scale demanding experiments and Rapid processing of precious products.
CRIO-MD Method Development columns for HP-RFC Pilot & Process columns
Creating a scale-down model of a Pilot or Process HP-RFC column requires the most fundamental characteristics to be preserved. Expressing the radial column as a "slice column" with the same bed height, frit buildup and the same ratio between inlet & outlet opening, This will ensure similarity of chromatographic performance.
Also the Annular packing port position and handling are identical to their larger counterpart hence even the packing density will be very close to the full scale column it represents.
The radial mimic MD column can therefore be considered a true "piece of (the) cake".
Pilot-scale Stainless Steel HP-Radial Flow Columns
Full radial columns with short to medium bed height and bed volume between 2 liter and 100 liter. Manually operated packing port. Pilot production under cGMP conditions.
HP-RFC Industrial Line Columns
Up to 30cm bed height
•Light weight small footprint columns for flexible clean room planning
•Rapid automated column packing 10-30 min
•Column volume 100 L up to 1200 L