Experts in Liquid Chromatography and associated technologies

Home > Products > Contichrom & SMB Systems

KNAUER Contichrom & SMB systems

Contichrom® Lab-10 LC system

all-in-one purification equipment with a novel process principle

Contichrom Lab-10 LC system:

 

The Contichrom prep-scale LC system allows to use multiple process principles such as batch chromatography, sequential multi column chromatography, simulated moving bed (SMB), CaptureSMB and the novel MCSGP principle with the same equipment.

 

The "multicolumn countercurrent solvent gradient purification" (MCSGP) process is based on the internal recycling of side fractions. Advantages of MCSGP in comparison with batch chromatography are a 50 % increase in yield and purity at 10-fold throughput and 70 % less eluent consumption.

Contichrom® Lab-100 LC system

all-in-one purification equipment with a novel process principle

Contichrom Lab-100 LC system:

 

The Contichrom prep-scale LC system uses standard columns and resins and is designed for the efficient chromatographic purification of proteins, peptides and small molecules. The Contichrom prep LC system with a flow rate of 0.1 – 100 ml/min can process up to 200 g product per day. It can be used from discovery to production:

  • Discovery: mining for and enrichment/isolation of novel leads
  • Process development: speed up development of robust processes and efficiently isolate impurities
  • Production: production of R&D and pre-clinical trial material amounts

SMB System CSEP® C9116 pilot unit

all-in-one purification equipment with a novel process principle

SMB System CSEP® C9116 pilot unit:

 

The Pilot SMB System CSEP C9116 is designed for the extraction of pure substances in gram-scale.

As with the large SMB system CSEP C9812, special emphasis is put on the continuous operation mode and high productivity. The system works thermostatically and can be operated with up to 16 SMB separating columns of the same type. The patented multifunctional valve drastically reduces the dead volume and provides for the compact design. The system is very efficient due to the continuously fed product being distributed over the entire stationary phase.

SMB System CSEP® C9812 production unit

all-in-one purification equipment with a novel process principle

SMB System CSEP® C9812 production unit:

 

The SMB System CSEP C9812 Production Unit is designed for the extraction of pure substances in kilogram-scale. Special emphasis is put on the continuous operation mode and high productivity.

 

The system works thermostatically and can be operated with up to 12 SMB separation columns of the same type. The patented multifunctional valve drastically reduces the dead volume and provides for the compact design. Due to its mode of operation, the system works very efficiently.